Police say the man walked into the Walgreens at Clinton and Brawley around 9:30 p.m. Tuesday night.
They say the suspect showed two clerks a gun and demanded money. After taking cash, he then ran out of the store.
Witnesses say the suspect looked like he was in his early 20's or late teens wearing a grey sweatshirt, dark-colored beanie, and black & white Nikes.
If you have any information about this incident call the Fresno Police Department at (559) 621-7000.