Sheriff's deputies arrested Smith on Saturday for the murder of 23-year-old Anthony Romero.
Investigators say the incident began as a domestic dispute and ended with Romero dying in the hospital from stab wounds.
It happened inside a home near Holland and Argyle Avenues on Saturday at around 4:30 p.m.
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Deputies have not released many details in their investigation.
A brother of the victim believes Smith was a friend.