The store will welcome customers at 9 am at the Boulevard at Sequoia Shopping Center. That's on Mooney Boulevard.
The opening of the store will mark the first time in 13 years a major book retailer has operated in the city.
The store features the Barnes & Noble Cafe with a Starbucks.
Officials say there will be events throughout the day for the opening.
Store hours will be 9 am to 8 pm Monday through Saturday, and 10 am to 8 pm on Sundays.