RELATED: Jury awards $2 billion to Livermore couple who says Roundup caused cancer
Monsanto has faced numerous lawsuits over claims it causes cancer.
In a statement Wednesday, Bayer said it was also paying up $1.22 billion to settle two further cases, one involving PCB in water.
RELATED: Roundup maker Monsanto appeals $78.5 million verdict over Bay Area man's cancer
The Leverkusen, Germany-based company said the Roundup settlement would bring closure to approximately 75%'' of the current 125,000 filed and unfiled claims. It said the agreement is subject to approval by Judge Vince Chhabria of the U.S. District Court for the Northern District of California.