Officials say his body was found in the roadway near Ventura and F Streets near the Poverello House around 2:10 am.
Investigators say the man had cuts on his face and was declared dead at the scene.
Police are investigating the victim's death as a homicide.
Officials say the area is a highly populated are for the homeless and they're working to speak with possible witnesses.
Anyone with information is asked to call the Fresno Police Department.