CAL FIRE Fresno County firefighters responded to the area of Buckeye Heliport along the highway just before 5:30 p.m.
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Crews were able to douse the flames and rescue the driver. The victim was airlifted to Community Regional Medical Center with major injuries.
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The cause of the crash is under investigation, but CHP officers believe the driver may have had trouble with the brakes.
This is a developing story.