Officers responded to a crash call just after 7 a.m. Monday on Kamm and Jameson avenues just west of Caruthers.
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Upon arrival, they confirmed the crash involved a Toyota Camry and a big rig.
CHP officers say the big rig driver was headed north on Jameson Avenue when he failed to stop for a posted sign and ran into the Camry.
The Camry driver died at the scene.
The men in the big rig were not wearing seat belts, CHP officers said.
The CHP is asking people to avoid the area as the investigation is ongoing.
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