Officials say the driver of a Toyota crashed on Highway 145 at Road 33, between Madera and Madera Ranchos, around 5:15 am.
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A passenger was ejected from the car during the collision. They were taken to a hospital, where they later died. Their name has not been released.
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CHP investigators say the driver of the car is expected to be OK.
The cause of the crash is under investigation.