Officers say the crash happened just before 1 a.m. on interstate-5 and Lassen Avenue, just north of the Kings County line.
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Investigators say the driver crashed into the center divide, causing the car to roll over several times.
All three people inside the car were ejected.
The driver, a man in his early 20s, died at the scene.
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The other two passengers, women also in their early 20s, were taken to the hospital.
Their condition is unknown.
DUI is not a suspected factor in the crash.