It happened near Firebaugh at around 6 p.m.
CHP says the driver of a Honda Civic was traveling eastbound on Shields Avenue, approaching Russell Avenue and failed to stop at a stop sign.
The big rig hauled two flatbed trailers to slam into the driver's side of the car-killing the San Jose man upon impact.
The big rig driver was not injured. Drugs and alcohol are not believed to factors.