The California Highway Patrol says it happened just after 8 pm near Jensen and Valentine.
Authorities say the cars collided when the big rig was going west on Jensen and a pickup truck was going north on Valentine.
Witnesses told officers the man in the pickup truck ran a stop sign.
The man in the truck died at the scene. The big rig driver did not suffer any injuries.
Authorities say it does not appear the man was wearing a seatbelt at the time of the crash. They added that alcohol does not appear to be a factor.