The crash involving four vehicles happened around 4 pm in the area of Willow and Olive Avenues.
Fresno police say a man was speeding when he ran a red light at the intersection.
The car hit another vehicle, causing a chain reaction crash.
Seven people were taken to the hospital with injuries.
Officials initially said five people were critically injured, but they are now expected to be okay.
Investigators say they believe the driver who ran the red light was driving under the influence of alcohol.
The driver is expected to be booked into the Fresno County Jail once he's released from the hospital.
Stay with Action News for the latest updates on this developing story.