The crash was reported just before 5 a.m. Friday near Road 144 and Avenue 400 east of Cutler.
Officers say two cars collided on Road 144 sending one of them into the canal. A person who saw the crash happen stopped and jumped into the canal to rescue a man.
When the victim was pulled from the water he was unconscious but still breathing. He was flown to a hospital but his condition is unknown at this time.
Officers say they believe there is no one else in the submerged vehicle but they are sending a dive team in to double check.