The crash was reported at 6:20 a.m. near Templin Highway, according to the California Highway Patrol.
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A photo from the scene, tweeted by Caltrans, showed at least two cars that crashed into the overturned big rig carrying lettuce. No injuries were immediately reported.
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All southbound traffic was being diverted to the eastbound 138 Freeway but all lanes were reopened for drivers shortly before 11:30 a.m.