The fire started after 11:30 pm at Fountain Way and Sierra Vista Avenue.
Investigators say the fire broke out above the kitchen and a bedroom area.
Residents quickly escaped the home when they smelled smoke.
Firefighters say their biggest challenge was a car parked in front of a hydrant. They say it slowed their response because of delayed access to water.
The Red Cross is helping the residents of the home find a new place to stay.
The cause of the fire is under investigation.