The man has been identified as 33-year-old Abraham Barajas-Cedillo.
Madera County sheriff's deputies were called to a house on Road 15 3/4 near Highway 152 after 9 pm on Thursday.
Barajas-Cedillo had been shot multiple times. First responders tried to treat him, but he died at the scene.
Investigators are working to determine what led up to the shooting.
Based on witness descriptions of the suspects, detectives are seeking at least two men. Both were wearing masks and clothing to conceal their identities.
Detectives believe the killing may have been gang-related.
This marks Madera County's first homicide of 2022.
Anyone with information is asked to contact Sergeant Noland or Corporal Gutierrez at (559) 675-7770.