The fire was reported around 6:30 a.m. on Sycamore Street just south of Avenue 22 1/2 in Fairmead.
Firefighters from Madera County Fire and Chowchilla Fire arrived to find a double-wide trailer engulfed in flames.
Officials say people were inside when the fire started, but everyone was able to make it out safely.
The home was destroyed, and so was a vehicle.
Firefighters say grass surrounding the trailer also caught fire, but crews were able to contain the flames.
A cause for the fire has not yet been released.