The impact sent both vehicles into a nearby vineyard. The truck overturned and the Charger burst into flames.
Two people were killed in the Charger and three people in the truck also died from their injuries.
Five people dead after vehicle and truck collide in Madera
Officials say it is too soon in their investigation to tell if alcohol or drugs played a factor in the crash.
The identities of the other four victims have not yet been released.