It happened just before 3 am at the store on Willow and Nees.
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Officers found a front window smashed. They followed a vehicle that was driving away.
They pulled the car over and arrested 23-year-old Kevin Loera of Fresno, 19-year-old Malik Davis-Easter of Fresno, 24-year-old David Rocha of Fresno, and a 17-year-old boy.
"Obviously, nothing good can come from this. There have been quite a few pharmacy burglaries recently," said Clovis Police Sgt. Jim Koch. "A lot of stores are beefing up their security. They are making it more difficult for people to break into their stores. But unfortunately, in this case, they were able to smash a window and get inside."
Investigators found approximately 10,000 pills inside their vehicle, including Xanax.
Flint Andersen with Parents and Addicts in Need says these stolen pills are ending up in the hands of Valley teens and contributing to addiction.
"These pills are deadly. These kids are going to take more than the recommended dose," he said. "If they are taking fentanyl and putting Xanax on top of it, the chances of them living are slim to none."
He warns parents to look out for changes in their teens and even children, in the event that the drugs stolen from local pharmacies end up in their hands.
"Experimentation is going to kill someone and I guarantee a parent does not want to go down that road," said Flint.
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Loera, Davis-Easter and Rocha were booked into the Fresno County Jail on charges of burglary and conspiracy. The teen was booked into the Fresno County Juvenile Center.