According to officers, the driver was traveling westbound on the highway at around 8:30 p.m. when he crossed the center divider into the eastbound lanes, striking three other vehicles.
Officers found the man about a mile and a half away from the scene.
His vehicle is registered out of Firebaugh and officers say he will be booked for felony DUI hit-and-run.
CHP says several people who were in the vehicles that were hit received minor injuries.