The crash happened around 1 pm on Highway 43 near Grangeville Boulevard, just northeast of Hanford.
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The California Highway Patrol says a Nissan traveling north on Highway 43 drifted to the right shoulder.
The driver over-corrected into the southbound lanes, sideswiping the cab of a semi truck and spinning into the path of another vehicle.
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The driver of the Nissan, a 25 year old man from Fresno, died at the scene.
The cause of the crash is still under investigation.