Fresno police say it happened just before 9 pm Sunday at the corner of Merced and Fulton streets.
Witnesses say there was a physical altercation between a group of people at the corner before the suspect began shooting.
A man in his 20s suffered at least one gunshot wound.
A witness drove the man to Community Regional Medical Center, where he is expected to survive.
Police say the suspect left the scene and there is no description at this time.