It happened just before 3 am Monday on Highway 33 at Bass Avenue.
Officers say a 27-year-old man from Mendota was driving a Chevy Equinox south, just north of Bass Avenue.
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They say he ended up crossing over into the northbound lanes of Highway 33 and hit a Toyota Corolla driven by another man from Mendota.
The driver of the Toyota died at the scene.
The driver of the Chevy suffered moderate injuries and was arrested for DUI.
Stay with ABC30 for the latest details on this developing story.