It happened Thursday evening near the community of Yettem.
Officers say the 41-year-old driver was traveling south on Road 144 north of Highway 201 when he drifted into the opposite lane and collided head-on with an oncoming Honda.
The 41-year-old man was arrested for driving under the influence and taken to Kaweah Health Medical Center in Visalia, where he died a couple of hours later.
The 67-year-old driver of the Honda was also taken to Kaweah Health with moderate injuries.