It happened after 12:30 Tuesday morning at Clinton and Maple.
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California Highway Patrol Officers say a Dodge van ran a red light and crashed into a Honda civic.
The car caught fire and had major front-end damage.
The van went off the road and hit a building.
The Honda driver suffered major injuries and was taken to the hospital.
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Officers say the Dodge driver was arrested on suspicion of driving under the influence.
"This is totally preventable," says CHP Sgt. Nicholas Ranger. "Take an uber, get a ride, call a friend, stay somewhere to sleep it off. This is preventable and didn't need to happen."
A witness called 911 about the crash.
The Dodge driver was also taken to the hospital for his injuries.