It happened at Shaw Avenue and Golden State Boulevard just before 2:30 p.m.
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Officials say the motorcyclists were traveling at a high rate of speed on westbound Shaw when they crashed into a big rig turning north.
Officers say both motorcyclists were unresponsive and transported to Community Regional Medical Center, where a 25-year-old rider later died. The second motorcyclist, a 32-year-old man, has critical injuries.
Traffic on eastbound and westbound Shaw between Blythe and Golden State was shut down following the crash.
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Investigators are working to determine if drugs or alcohol were a factor in the crash.
This is a developing story. Stay with Action News for updates.