Nearly half of those who died were not wearing seatbelts.
CHP officers also issued more than 9,700 speeding tickets during the holiday enforcement period, defined as Friday night through Tuesday night.
Officers also made 1,224 arrests for driving under the influence, or an average of one every 5 minutes.
"All of these deaths were preventable, and the loved ones they leave behind will be forever impacted," said CHP Commissioner Sean Duryee. "Traffic safety is everyone's responsibility, and these statistics show us how much work there is still to be done."