CHP officers stopped a vehicle in the area of Highway 99 and Tulare Avenue around 7:30 pm.
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The Tulare County High Intensity Drug Trafficking Area Unit was called out and they found 150,000 fentanyl pills in the vehicle.
Investigators say the street value is $750,000.
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25-year-old Jose Zendejas and 19-year-old Benito Madrigal, both from Washington, were booked into the Tulare County Pre-trial facility for the possession and transportation of illegal drugs.
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A court later ordered the release of the two suspects on their own recognizance.