Authorities say 33-year-old Joe Alvarez and his daughter, 13-year-old Analiea Alvarez, of Fresno, died in the crash on Highway 180 and Alta Avenue.
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Officers say Joe was speeding in a Jeep Liberty when he swerved into oncoming traffic, crashing head-on with a Chevy pickup truck.
Joe was thrown from the car. He was declared dead at the scene.
Analiea was airlifted to the hospital, where she died.
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The man in the Chevy was taken to the hospital for treatment.
His 16-year-old and 4-year-old children in the truck were not hurt.
It is not known if drugs or alcohol were factors in the crash.