Authorities have identified the woman as 47-year-old Shamone Tshimika.
The California Highway Patrol says it happened around 6:30 pm near Clovis and Manning.
Officers say a Toyota Corolla was going west on Manning when a Honda Odyssey exited out of a vineyard onto Manning and got broadsided.
Tshimika was taken to the hospital, where she died.
Officers say drugs or alcohol are not factors in the crash.