Authorities have identified the man killed as 31-year-old Boon Thao.
The crash happened just before 5:30 Saturday morning on Minnewawa between Shepherd and Behymer.
Investigators are looking into the cause but say two SUV's collided when a honda veered into oncoming traffic, hitting a Cadillac.
Thao was the driver of the Honda and was pinned in the crash and died from his injuries. The other driver was treated for minor injuries.
The roadway has since reopened after being shut down for several hours.