Authorities have identified the man as 36-year-old Miguel Rodriguez Felix.
CHP officials say the crash occurred a little before 2 pm on Tuesday in the area of Jameson Avenue west of Manning Avenue.
They say it looks like Felix was driving the wrong way down Jameson Avenue - northbound in the southbound lane.
He lost control of the vehicle, causing it to overturn.
Felix was ejected from the vehicle and died of his injuries at the scene.
The CHP says alcohol appears to be a factor.