They say 31-year-old Andre Hill, Jr., crashed his semi truck into a car driven by 19-year-old Olivia Mendoza at Mountain View and Clovis just after 7 p.m.
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He also crashed head-on into another semi, but that driver suffered only minor injuries.
Officers say the Baltimore, Md., truck driver couldn't walk a straight line and they believe he was high on marijuana.
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CHP officers arrested him for gross vehicular manslaughter while intoxicated and other charges. His bail is set at $98,500.