It happened just before 6:30 p.m. near the intersection on California and Cornelia Avenues.
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California Highway Patrol officers say 56-year-old Sixto Lopez was headed east on California Avenue when he drifted into the westbound lane and crashed head-on into an oncoming Chevrolet.
Officers say Lopez suffered major non-life-threatening injuries and was taken to Community Regional Medical Center.
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Three people were inside the Chevy, including a 13-year-old and 17-year-old boys. The teens suffered minor injuries and were also taken to CRMC. The driver, 44-year-old Kenda Gutierrez, was not injured.
Lopez was arrested for DUI and booked into the Fresno County jail.