The California Highway Patrol says it happened at the intersection of Highway 41 and Adams Avenue.
Officers say the driver of a Chevy pick-up ran a red light and was hit in the intersection by a Peterbuilt gas tanker.
The driver of the Chevy suffered major injuries and was taken to the hospital.
The driver of the semi-truck sufferred minor injuries.
Officers say the driver of the Chevy was not wearing a seatbelt.