Deputies and the SWAT team responded to a domestic violence call on Auberry Road north of Highway 168 at around 3 a.m on Wednesday.
Officials say the 68-year-old man was threatening his wife and the responding law enforcement.
Deputies say they stayed on the phone with the suspect for nearly six hours before finally convincing him to come out of the residence.
He is currently in the hospital and in custody.
Investigators say the man's wife had initially been inside the home, but made it out safely.
Auberry Road at Frazier was closed for hours and detours were in place as authorities worked to bring the situation to a conclusion.
If you are the victim of domestic abuse, or you know someone who is, there is help available 24/7. In Fresno County, call the Marjaree Mason Center at (559) 233-4357. In all other locations, call the National Domestic Violence Hotline at (800) 799-7233.