It happened around 8:30 pm.
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Fresno police say the truck driver was traveling north on Channing when they collided with a Tesla that was headed west on McKinley Avenue.
The crash impact sent the Tesla into a yard and the truck through a house where someone inside.
The homeowner said he was sitting on a couch and narrowly escaped serious injury.
"My house is on a sub-floor, which is raised up, so I think that's what slowed the vehicle from going all the way through the house, but it could've been more serious. I mean, just getting pushed off the couch to the middle of the living room," he said.
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The homeowner suffered minor injuries but is expected to be OK.
Police say the driver of the truck failed a sobriety test and will likely face DUI charges.
The driver of the Tesla is in the hospital with injuries. They are also expected to be OK.