Officials say a silver Ford Mustang and silver Prius were traveling on southbound Highway 41 near the O Street off-ramp around 1:10 pm when they collided.
The Prius ran off the road and hit a guard rail and a tree as it crashed down an embankment, the CHP said. A passenger inside died at the scene.
Another person was transported to the hospital with moderate injuries. It's unclear if any other people were injured.
Investigators have not yet determined the cause of the crash.
The O Street off-ramp is closed to traffic. Drivers are advised to avoid the area as officers continue their investigation.
This is a developing breaking news story. Stay with Action News for updates.