Fresno County sheriff's deputies tried to pull the driver, identified as Steven Hernandez, over just after 1:00 a.m. at First and McKinley for failing to stop at a red light.
Hernandez took off, and a pursuit began through city streets at speeds over 90 miles per hour.
As he tried to turn on Rowell Avenue near Belmont, his car hit a stop sign and smashed into a nearby tire shop.
Hernandez tried to get away, but the car was stalled.
Deputies say he has a warrant for failing to register as a sex offender.
His female passenger was also taken to the hospital for injuries suffered during the crash.