Police identified the victim as 26-year-old Joseph Riley. A 19-year-old was also shot but is expected to survive.
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Authorities responded to a ShotSpotter alert and calls of shots fired near Blackstone and Princeton Avenues.
Police say through surveillance video, they found that three people inside a smoke shop waited for the victims to arrive before shooting at them.
The victims left the store and two suspects chased them while still firing.
Riley died from his injuries.
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Authorities are still working to identify the suspects.
Anyone with more information is asked to contact the Fresno Police Department.
EDITOR'S NOTE: The video above is from a previous broadcast and will be updated.