Fresno police were called to the area of Belmont Avenue and Fulton Street just after 3:00 am.
A woman reported a man had been shot. Officers found a small gunshot wound in his back.
The man was rushed to Community Regional Medical Center, where he later died.
Police identified the man as 24-year-old Jacob Williams of Fresno.
Further information regarding what led up to the gunfire or a motive for the shooting has not been released.
Police have the area blocked off as detectives continue their investigation.