The shooting happened at an apartment complex in the area of S Clara Ave and E Lorena Ave.
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Fresno police say that at about 6 pm, neighbors called 911 after hearing gunshots.
21 rounds were fired, according to ShotSpotter. Officers arrived to find four people shot.
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Two of them, 43-year-old Roman Cervantes and 27-year-old Jose Herrera Mojica, died from their injuries at the scene.
Two others, another man and a boy, were rushed to the hospital where they are receiving treatment for gunshot wounds.
Investigators say there had been a disturbance before the shooting.
Police are looking for suspects seen running away from the area after the shooting. They are currently interviewing witnesses.