The incident occurred near O Street and Mariposa Street at about 10 on Saturday morning.
CHP says the stabbing occurred after the woman, who is homeless, confronted the man, who was rummaging in her belongings.
The two then had a physical altercation, during which the man stabbed her repeatedly with an unknown object, according to the CHP.
She was rushed to CRMC.
Anyone with information about the incident is asked to call the CHP at 559-262-0400.
They are investigating the incident as attempted murder.