The highway closed at Grapevine Road shortly before 11:30 am.
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Firefighters were working to douse the fire and clear the smoke before Caltrans crews reopen the lanes.
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Drivers traveling north toward the Central Valley are advised of possible delays.
In Kern County, California Highway Patrol in Fort Tejon temporarily shut down the southbound and northbound lanes in Kern County after loads of hay spilled onto the lanes and fire broke out. The southbound lanes have since reopen.
Officials say the Kern County Fire Department has responded to the fire.