It happened just after 10:30 am on Gurr Road South of Shippee Road.
The California Highway Patrol says the woman drove her Toyota Corolla into the opposite lane and crashed head-on with a Chevy Silverado.
The woman died at the scene. Officers say she was not wearing a seatbelt.
The driver of the Chevy suffered minor injuries. Officers say he is cooperating with the investigation.
It is not known why the woman veered into oncoming traffic.