MADERA COUNTY, California (KFSN) -- The crash happened around 2 a.m. Wednesday, on the interchange where Highway 152 turns into Highway 99.
Investigators say the driver of a Jetta was headed east when he drifted into oncoming traffic and collided with a big rig, head on. The driver died at the scene. It's unknown why he was driving on the wrong side of the road.
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The victim's name has not been released, but officials say he is from Madera.
The CHP is expecting a section of the highway to be reopened early Wednesday morning.