Matthew Hurst, 50, of Fresno, died after crossing into oncoming traffic on the highway, colliding head-on with another driver going north toward the Friant off-ramp.
Hurst was pronounced dead at the scene.
The second driver, a 56-year-old man, suffered minor injuries.
The California Highway Patrol has not yet determined a cause for the crash.
EDITOR'S NOTE: The previous version of the story said that a woman was killed in this crash. We apologize for the error.