The crash happened before 11 pm on the northbound 99 near Merced Street.
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The California Highway Patrol (CHP) says the driver of the sedan pulled over because of a flat tire, and stepped out of the car.
Moments later, a big rig collided with her vehicle, pushing it nearly 700 feet into the third lane.
Both the sedan and semi caught fire and are completely destroyed.
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Despite the heavy damage, no one was hurt.
Crews are working to reopen all lanes soon as they remove the wreckage.