Officials say a tanker truck and a big rig collided, spilling Chloride onto the northbound lanes of the highway.
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Northbound traffic is being diverted to Lebec Road to bypass the spill. Southbound traffic has reopened.
Crews will likely take 3-4 hours to clean up the spill, the CHP says.
Caltrans says the westbound State Route 138 and northbound I-5 connector is also closed.
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