The crash involved three vehicles and happened on Highway 41 and Grangeville at 3 pm.
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California Highway Patrol officers say the driver of a Chevy Silverado hit the victim's Nissan from behind. The Nissan then hit the Ford in front.
The driver of the Nissan died of his injuries.
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CHP officers say they do not yet know what caused the collision, but that alcohol or drugs may have played a role.